In Situ Functionalized Polymers for siRNA Delivery
نویسندگان
چکیده
منابع مشابه
siRNA Delivery Improvement by Co-formulation of Different Modified Polymers in Erythroleukemic Cell Line K562
Objective(s): siRNA may be a very promising tool for treatment of various diseases especially in cancer therapy due to high specificity. One of the main hurdles applications of siRNAs in vivo is optimization of the delivery strategy, especially the carrier systems. The aim of this study was to optimize siRNA delivery into suspended erythroleukemic cell line K562. Materials and Methods: We appli...
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A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer comp...
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objective(s): sirna may be a very promising tool for treatment of various diseases especially in cancer therapy due to high specificity. one of the main hurdles applications of sirnas in vivo is optimization of the delivery strategy, especially the carrier systems. the aim of this study was to optimize sirna delivery into suspended erythroleukemic cell line k562. materials and methods: we appli...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2016
ISSN: 1433-7851
DOI: 10.1002/anie.201601441